Infant Brain Boost: Lutein

By: Anthony Thomas, Ph.D.


Fat-Soluble Antioxidant Carotenoids

                  Carotenoids are a class of more than 600 naturally occurring fat-soluble yellow, orange, and red pigment molecules made by plants, algae, and photosynthetic bacteria that exert antioxidant properties.  Carotenoids are often discussed because they support a wide range of health-promoting functions, but they can’t be made in the body—they can only be obtained from a diet rich in brightly colored fruits and green leafy vegetables, or through dietary supplementation.  Beta- and alpha-carotene (carrots, pumpkins, sweet potatoes), lycopene (tomatoes, watermelon), beta-cryptoxanthin (papyas, pumpkin), lutein and zeaxanthin (spinach, kale, chard) are the most common carotenoids in North American diets.


Lutein On The Mind: Young & Old 

                  Among dietary carotenoids, lutein is preferentially deposited in neural tissues and is the predominant carotenoid in both pediatric and adult brains.  In fact, the contribution of lutein to total brain carotenoid content in infants [Vishwanathan, R. Lutein is the predominant carotenoid in infant brain. Paper prsented at: 16th International Symposium on Carotenoids; July 2011; Krokow, Poland. Abstract] is approximately double that found in adults, accounting for more than half of total brain carotenoids, suggesting an important additional role in early development of the central nervous system. 

                  In adults, mounting evidence supports a role for lutein in cognitive function.  Lutein supplementation was associated with an improved cognitive function in older women [1] and lutein content within the eye, an extension of the neural system and positively correlated with lutein content in the brain [2], is related to cognitive performance in older adults [3-5].  Among carotenoids, only lutein was consistently associated with a wide range of cognitive functions in adults when examining levels of lutein in the brains of decedents from a population-based study [6]. 

                  Emerging scientific evidence supports a role for lutein in early human development as it is the most abundant carotenoid in cord plasma [7] despite not being the predominant carotenoid consumed in typical Western diets, and concentrations in the infant brain were significantly correlated with neurotransmitters involved in neural development [8].  It was also shown that administration of lutein in the first hours of life increased antioxidant capacity and lowered oxidative stress [9] during this period of vulnerability given the human newborn brain has relatively poor antioxidant defenses [10].


This Is The Brain & This Is The Brain On Lutein

                  Despite increasing interest in the role of lutein in brain development and its addition to some commercial infant formulas, its accumulation pattern in early life is not known.  Pilot research funded by Abbott Nutrition and recently published in the scientific journal Nutrients [11] showed that feeding lutein-enriched infant formula markedly augmented lutein accumulation in the brains of infant rhesus macaques.  These results are the first published report of brain lutein accumulation patterns in non-human primate infants supplemented with lutein.  

                  Non-human primates are the most relevant to study lutein and zeaxanthin, a related xanthophyll carotenoid, accumulation patterns in neural tissues because they are the only non-human animals that selectively accumulate lutein and zeaxanthin in their eyes and brain as humans do.  Researchers divided infant rhesus monkeys into two groups (n = 2/group; one male and one female in each group), with one group receiving formula enriched in lutein, zeaxanthin, lycopene, and beta-carotene, and the other group receiving non-enriched formula containing only a relatively small amount of lutein and beta-carotene over a period of four months. 

                  The lutein-enriched formula feeding resulted in several-fold greater lutein accumulation in all brain regions examined compared to the non-supplemented formula feeding.

PFC: prefrontal cortex; OC: occipital cortex; STC: superior temporal cortex; ST: striatum; CB: cerebellum; and HP: hippocampus


                  Total lutein accumulation was highest in the occipital cortex, the primary visual processing area.  Notably, macular lutein and zeaxanthin have established roles in supporting visual performance and optimal visual performance in early life may influence brain development, which occurs rapidly in the first year of life [12].  Additional tissues were also examined such as various fat depots as well as liver, lung, kidney, heart, quadriceps muscle, and spleen.  Lutein accumulation was also greater in all these tissues with consumption of the lutein-enriched formula.

                  The researchers concluded from their small pilot study that increased early intake of dietary lutein enhances lutein tissue deposition.  Future studies will be needed to investigate the turnover of lutein within these tissues and the potential influence of lutein on the development of the brain and/or other organ systems.


To The Eyes...And Beyond!

                  As supported by an extensive body of growing scientific evidence spanning recent decades (see graph below), lutein is most widely recognized for supporting visual function and eye health via protection of the macula from oxidative injury by filtering damaging near-UV/blue-light and scavenging free radicals (in combination with zeaxanthin isomers).  However, increasing scientific attention in recent years has been paid to the role of lutein in the brain and cognitive function given its predominance among carotenoids in the human brain of both infants and adults despite not being the predominant carotenoid consumed.

                   Fat-soluble antioxidants are pivotal to the retina and brain as photoreceptors of the retina and neuronal membranes are rich in long-chain polyunsaturated fatty acids (PUFAs), especially the omega-3 docosahexaenoic acid (DHA), which while critical to proper function, are highly susceptible to oxidation.  Thus, these tissues are vulnerable to oxidative injury due to their high oxygen consumption/metabolic activity and PUFA content.  Hence the need for relatively stable (slow turnover, resistant to self-oxidation), fat-soluble antioxidants for protection. 

                  Among dietary carotenoids, only the dipolar lutein and zeaxanthin, with their high membrane solubility and stability, selective enrichment in vulnerable PUFA-rich membrane domains of neural tissues, transmembrane (perpendicular) orientation within the membrane lipid bilayer (due to the presence of polar hydroxyl groups at each end of the molecules anchoring them at opposite membrane surfaces), high resistance to self-oxidation, and preferential accumulation in neural tissues, are uniquely positioned to protect the membrane integrity of these tissues [13]. 


Dietary Dearth

                  Infant formulas are not routinely enriched with lutein at present.  Breast milk on the other hand, is a highly bioavailable source of lutein [14], but content in breast milk is dependent on maternal lutein intake.  A meta-analysis of 11 studies indicated significantly higher scores for cognitive development in breastfed vs. formula fed infants, which may have been due in part to differences in exposure to dietary carotenoids including lutein [15]. 

                  Typical average intake of lutein and zeaxanthin, found primarily in dark leafy greens (e.g., kale, spinach, chard, broccoli), among the U.S. population, is insufficient at only 1.5 mg per day.  Supplemental sources are more efficiently absorbed since they do not need to be released from the plant matrix.  Thus, dietary lutein and zeaxanthin supplementation during pregnancy and lactation are advisable, particularly when supplementing with DHA, which is becoming more routine during pregnancy, lactation, and in infant formulas.   


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