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S-Adenosyl Methionine

Joint Strength*

Liver Detoxification*

Mood and Brain Function*

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  • Enteric-Coated
  • Central biochemical building block
  • Body's primary methyl donor*
  • 68-80% Active S,S Form
  • Made Naturally By Fermentation
  • Individually Blister-Packed


Jarrow Formulas® SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.


Contains More of the Active S,S Form

Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is  the (S,S) structure, while the (R,S) structure is biologically inactive.  Jarrow Formulas® SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.


SAM-e has been clinically shown to have the following benefits:


Joint Strength  

SAM-e supports the production of healthy connective tissue through transulfuration.* In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-e metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.*


Brain Metabolism

SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component  of lecithin).*



SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function, including phase II detoxification.*

Jarrow Formulas® SAM-e 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.


Full Potency 400 mg SAM-e (net yield)  is derived from 800 mg of SAM-e  tosylate disulfate.


For best results, use with Jarrow Formulas® JarroSil®, the biologically Activated Silicon®.


Store in a cool, dry place.

Keep out of the reach of children.


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Suggested Usage

Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional. 

WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Other Ingredients

Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch glycolate, and an enteric coating(methacrylate copolymers, magnesium silicate, titanium dioxide, triethyl citrate, silicon dioxide and riboflavin).

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.


Suitable for vegetarians/vegans.

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SAM-e is rated 5.0 out of 5 by 1.
Rated 5 out of 5 by from Jarrow Sam-e This is a fabulous product!...but it is so expensive. Are there any bargains out there? Thanks.
Date published: 2014-08-14
  • 2015-09-24T12:34CST
  • bvseo_cps, prod_bvrr, vn_cps_3.1.6
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_361, PRD, sort_relevancy
  • clientName_jarrow
Reformulation Date:
Design Change Date: 09/17/2013
Last Update: 03/24/2015
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Serving: 400 mg SAM-e Per Tablet Product Number: 120020
Size: 30 Enteric-Coated Tablets Product Code: SAM400
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